Introduction. The aim of this study was to make a quantitative assessment of interleukin-1b and inter- leukin-6 in crevicular peri-implant fluid from patients with favorable evolution and patients with peri-im- plantitis, and to find out if there is a correlation be- tween interleukin-1b and interleukin-6 values and the patient’s clinical status at 7, 30 and 90 days after the insertion of dental implants.
Methods. The study group comprised 32 patients: 5 patients with favorable evolution and 27 patients with different forms of peri-implantitis, selected from 220 patients with dental implants inserted during 1.01.2015-31.12.2016 in a dental private practice. Clinical oro-dental examination was performed at 7, 30 and 90 days after implants insertion. Also, at these moments, we harvested peri-implant crevicular flu- id from which interleukin-1b and interleukin-6 were quantified by ELISA method (Salimetrics, USA).
Results. We have found statistically significant dif- ferences between interleukin-1b mean values in the two groups of patients in all 3 moments of evaluation (p<0.001). There have been also statistically significant differences regarding interleukin-6 mean values be- tween the patients groups at the 3 evaluation moments (p<0.0001). The results showed that there is a high cor- relation between interleukin-1b and peri-implant sul- cus depth in patients with advanced peri-implantitis (p=0.0008, r=0.904) and a correlation between inter- leukin-6 and peri-implant sulcus depth in patients with advanced peri-implantitis (p=0.029, r=0.717).
Conclusion. Correlations between interleukin-6, interleukin-1b and peri-implant sulcus depth demon- strate the usefulness of quantifying these interleukins in monitoring patients with peri-implantitis and, in the same time, the opportunity to be included in the peri-implantitis diagnostic scheme.
Key words: IL-1b, IL-6, peri-implantitis.
PMN = polymorphonuclear IL-1b = interleukin-1b
IL-6 = interluekin-6 GI = gingival index
BOP = bleeding on probing PI = plaque index
PICF = peri-implant crevicular fluid