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Spironolactone Favored Over Clonidine for Resistant Hypertension

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Findings published online on February 20 in Hypertension from a Brazil report say that spironolactone appears to be a better fourth drug than clonidine for treating patients with resistant hypertension. Moderate doses of clonidine (an alpha-2 adrenergic agonist) were not superior to spironolactone (a diuretic antagonist of aldosterone). The rate of side effects was low for both treatments, and there were no differences in adherence rates.

(https://www.medscape.com/viewarticle/893626)

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