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Uterine fibroid and diffuse uterine fibromatosis – Two different entities – A prospective study

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Uterine fibroid or fibromyoma is a very common benign human tumor and the most frequent tumor in the woman’s reproductive system. Uterine fibroids affect millions of women across the world and they are still the most commonly surgically treated.
In Romania too, uterine fibroid is the most common reason for hysterectomy, about 60% of cases have this diagnosis preoperatively established. Uterine fibroid is a benign tumor that occurs very frequently in women of reproductive age. General prevalence of fibroids is between 20 and 40%
[1]. Prevalence varies by age and is higher in the final part of the fertile period, approximately 35-40% of women over 40 years old have uterine fibroids. The reported incidence is highly variable in different studies, in fact, to determine the exact prevalence of fibroids, a correct clinical research should apply ultrasound scanning in a randomly sampled population
[2]. On the other hand, women’s current trend of delaying pregnancy beyond the age of 30 years but also increasingly frequent disturbances of fertility have led to the need for uterine leiomyomas analysis in relation to fertility. We have assumed a great responsibility approaching this subject of research taking into account the high incidence on the one hand and the fact that the uterine fibroids are considered generally something very “common” in the gynecologic pathology that can no longer bring up nothing spectacular scientifically, on the other hand. We approached a prospective study which will analyze the histological, ultrastructural and immunohistochemical endometrium and myometrium in patients with uterine fibroids well defined compared to patients with diffuse uterine fibromatosis starting from the premise that these two aspects very similar to the uterine pathology are still different at ultrastructural level and in terms of involvement of different profibrotic and angiogenic factors but also in distribution of various hormone receptors. Partial results show differences statistically but not so important in terms of epidemiological, clinical and surgical terms.
Histological and immunohistochemical data will still be collected and processed to understand the similarities and especially the differences between these two entities.

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