ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

A model for predicting late complications of myocardial infarction in patients with type 2 diabetes mellitus

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Introduction. Late complications of myocardial infarction (MI) are important causes of re-hospitalization and mortality in patients with type 2 diabetes mellitus (DM).
The objective of the study was to predict the development of late complications after MI in type 2 DM patients, to improve the quality of diagnostic tests for this group of patients.
Material and methods. A total of 109 patients with type 2 DM after MI was divided into two groups: the study group (n = 74) and the validation group (n = 35). The levels of adropin and C1q/tumour necrosis factor-related protein 3 (CTRP 3) were measured by enzyme-linked immunosorbent assay. The model for predicting late complications of MI was calculated using binary logistic regression.
Results. The median age of patients was 61.0 (54.5 – 67.0) years and 68.8% were male. Mathematical model components on the 14th day of follow-up were qualitative adropin, qualitative CTRP3, total cholesterol (TC), triglycerides (TG), ejection fraction (EF), low-density lipoprotein (LDL), left atrium (LA). The model attained the highest under the receiver operating characteristic curve for predicting late MI complications in the study and control groups (0.949 and 0.966, respectively), with the highest diagnostic accuracy in both groups (94.6% and 97.1%, respectively).
Conclusions. This study has shown that the integral assessment of adropin, CTRP 3, TC, TG, EF, LDL, LA, measured on the 14th day after MI in type 2 DM patients who underwent percutaneous coronary intervention (PCI), could predict late complications of MI after PCI.
Keywords: complications, myocardial infarction, diabetes mellitus, model.

Full text sources https://doi.org/10.31688/ABMU.2022.57.1.05
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Address for correspondence:
Mariia KOTELIUKH
Department of Internal Medicine No. 2, Clinical Immunology and Allergology named after Academician L.T. Malaya, Kharkiv National Medical University
Address: Nauky Avenue no. 4, 61022 Kharkiv, Ukraine
Email: koteliukh@gmail.com; Phone: +38 097 943 0602

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Koteliukh MY. A model for predicting late complications of myocardial infarction in patients with type 2 diabetes mellitus. Arch Balk Med Union. 2021;57(1):36-44. https://doi.org/10.31688/ABMU.2022.57.1.05