ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Analysis of plasma biomarkers as an indicator for early diagnosis of acute mesenteric ischemia in rat


Objectives. The aim of the present study was to investigate the correlation between routine plasma markers after acute mesenteric ischemia, in order to determine an algorithm which could provide early diagnosis of the disease.
Methods. Fourteen male Sprague Dawley rats were allocated into two groups: Group I (n=7) – Partial ischemia group; Group II (n=7) – Diffuse ischemia group. Blood samples were taken three times for each animal: preoperatively, as well as at 24 hours and 48 hours after the ischemia. Changes within each test, as well as the correlations between them, were investigated.
Results. There were almost no changes in the level of BUN and CRP values after ischemia. Similarly, ALT and C3 levels were only minimally increased (p>0.05). However, AST, LDH and fibrinogen levels significantly increased in the first 24 hours after the mesenteric ischemia, then reduced minimally 48 hours later (p<0.05).
Conclusion. Partial and diffuse acute mesenteric ischemia caused a decrease in blood glucose, increases in AST, LDH and fibrinogen and no significant changes in ALT, CRP, BUN and C3 levels in the rats.

Keywords: mesenteric ischemia, plasma marker, biochemical.

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