ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Clinical manifestations and burden of HPV infection – prevention and therapeutic possibilities



Human Papilloma Virus (HPV) is the virus responsible for the most common and widespread sexually-transmitted infection. Most sexually active people will acquire at least one type of HPV  in their lifetime and some may be repeatedly infected. In most cases, HPV infection is transient and asymptomatic, but when the infection persists it can cause benign diseases, precancerous lesions and malignancies of various locations. Low risk HPV types can produce proliferative lesions either in the skin or mucosa, whereas high risk types possess carcinogenic potential. This paper is a review of the latest data in the literature regarding the clinical manifestations of HPV infections, current prevention and therapeutic possibilities.

Keywords: HPV infection, carcinogenic potential, anogenital warts.


CDC – Centers for Disease Control and Prevention

CIN – cervical intraepithelial neoplasia

HPV – human papillomavirus

Hsp-E7 – heat shock protein

KTP – potassium titanyl phosphate

MMC – mitomycin C

MMR – measles-mumps-rubella

PD-L1 – programmed death-ligand 1

POD-NLC – podophyllotoxin-loaded nanostructured lipid carrier

RRP – recurrent respiratory papillomatosis

VEGF – vascular endothelial growth factor

VLPs – virus-like particles

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Cioti AM, Stanescu AMA, Grajdeanu IV, Miricescu D, Serban B, Bratu OG, Diaconu CC. Clinical manifestations and burden of HPV infection - prevention and therapeutic possibilities. Arch Balk Med Union. 2019;53(4):739-744.