Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system It occurs in patients with severe cellular immunodeficiency such as HIV infection, being one of the AIDS-defining illnesses. The prognosis of this disease was reserved before combined antiretroviral therapy (cART). Recently, it has been noticed a favorable evolution in patients receiving cART with good penetration in CNS. On the other hand, in PML, the location and the mass effect have prognostic implications. In this article the authors present two cases of PML in HIV positive patients, one who survived and other one who presented evolution to death.
Keywords: progressive multifocal leukoencephalopa- thy, HIV, AIDS, John Cunningham polyoma virus.
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