ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Immune thrombocytopenic purpura: New perspectives for diagnosis and treatment


Immune thrombocytopenic purpura (I.T.P) is a bleeding disorder that associates purpura and thrombocytopenia. Purpura is the form of manifestation of this pathology, caused by the extravasation of red blood cells in the dermis due to reduction in peripheral platelets. Trombocytopenia involves the decrease of blood platelets under 100,000 elements mm3 blood.
This is due to either a premature hyper-destruction of peripheral blood or to a bone marrow deficient synthesis. ITP involves anti-platelet antibodies whose action induces morphological and functional changes at the platelet level.
ITP has two forms: primary, idiopathic or secondary, emerging in the context of associated pathologies. Differential diagnosis is one of exclusion. It involves exclusion of autoimmune diseases, viral or bacterial infections, lymphoproliferative syndromes likely to induce secondary thrombocytopenia.
The accurate establishment of the factors involved in chronic immune purpura etiopathogeny leads to a correct diagnosis and to the establishment of the optimal therapeutic regimen.

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