ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Spironolactone Favored Over Clonidine for Resistant Hypertension


Findings published online on February 20 in Hypertension from a Brazil report say that spironolactone appears to be a better fourth drug than clonidine for treating patients with resistant hypertension. Moderate doses of clonidine (an alpha-2 adrenergic agonist) were not superior to spironolactone (a diuretic antagonist of aldosterone). The rate of side effects was low for both treatments, and there were no differences in adherence rates.



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