Introduction. Breast cancer is the most common cancer among women. Though there is an annual increase in its incidence, the mortality remained relatively stable, probably reflecting the combined benefits of early detection and better treatment. During the 1980s, large randomized clinical trials had shown that breast conservative therapy became the treatment of choice for early breast cancer. Several risk factors for local recurrence after breast conservative surgery have been recognized: margin status, young age and other.
The objective of the study was to assess the effect of age and safety margin on local recurrence and survival after breast conservative surgery for early breast cancer.
Material and method. The study included 200 female patients admitted to the Al Amal Oncology Center, Yemen, with the diagnosis of early breast carcinoma (stage I, II), between January 2012 and December 2016, and treated with breast conservative surgery.
Results. The result of our study showed that 53 (26.5%) of female patients were ≤ 40 year-old, while 147 (73.5%) were > 40 year-old. 14 patients (7%) had recurrent ipsilateral breast tumor in this study. Regarding safety margin (SM), 190 patients had negative margin, 4 patients close margin and 6 patients were with positive margin. The five year overall survival rate in patients ≤ 40 year-old was 80.4%, while in patients > 40 year-old was 87.1%. The five year overall survival rate in patients with (+)ve SM was 53.3%, 75% in those with close margin and 86.5% in those with (-)ve margin, which was significantly higher than (+) ve or close SM (p =0.001).
Conclusion. In this study, we found that age and safety margin were independent risk factors for local recurrence and survival.
Key words: breast cancer, conservative surgery, recurrence.
Abbreviations: BCS: Breast conservative surgery,
AJCC: American Joint Committee on Cancer, DFS:
disease free survival, OS: overall survival, NHG:
Nottingham Histologic Grade, SM: safety margin, SE: