A meta-analysis of 235 articles, published in European Heart Journal in October 24, 2017, has concluded that CPAP therapy might reduce major adverse cardiovascular events (MACE) and stroke among subjects using continuous positive airway pressure therapy (CPAP) more than 4 hours/night. The article, authored by Khan SU, Duran CA, Rahman H et al, searched articles published in journals indexed in MEDLINE, EMBASE and Cochrane library. These studies included 4268 patients and demonstrated a non-significant 26% relative risk reduction in MACE with CPAP. The subgroup analysis showed that CPAP adherence time ≥ 4 hours/night reduced the risk of MACE by 57%. CPAP had positive effect on mood and reduced the daytime sleepiness, evaluated by Epworth Sleepiness Scale. Further studies are necessary to evaluate the impact of CPAP time adherence on MACE.