A study published online in October 23, 2017, in BMJ Open Diabetes Research & Care, by lead author Jill P Crandall, MD, department of medicine and diabetes research center, Albert Einstein College of Medicine, New York, and colleagues, has found that “Long-term statin use is associated with an increased risk of type 2 diabetes of approximately 30% in individuals at high risk of the disease, even after taking into account known risk factors and potential confounders. The findings are consistent with previous studies suggesting that statin use substantially increases the risk of type 2 diabetes”.
In this study, there were included 3234 US patients randomized to intensive lifestyle intervention, metformin, or placebo, who received simvastatin, atorvastatin, lovastatin or pravastatin. The patients were followed-up for 3.2 years.
“For individual patients, a potential modest increase in diabetes risk clearly needs to be balanced against the consistent and highly significant reductions in myocardial infarction, stroke, and cardiovascular death associated with statin treatment,” they state.
“Nonetheless, glucose status should be monitored and healthy lifestyle behaviors reinforced in high-risk patients who are prescribed statins for cardiovascular disease prophylaxis.”