ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

The role of homocysteine and other endogenous intoxication markers in the pathogenesis of lichen planus



Introduction. Lichen planus (LP) is a chronic poly-etiologic dermatosis by the mechanism of its development, manifested by papular rash on the skin and mucous membranes, severe itching.

The objective of the study was to determine and analyze the levels of endogenous intoxication markers in blood plasma of the patients with lichen planus depending on severity and duration of the disease.

Materials and methods. 48 patients, 20 men and 28 women, participated in the study. 31 patients had suffered from dermatosis for about 2 years, and 17 patients for over 2 years.  Mild LP was diagnosed in 17 patients and moderate LP in 31 patients. The blood levels of homocysteine (HC), carbonyl groups of oxidative modified proteins (CG-OMP) and medium molecular weight peptides (MMWP) were determined in all the patients.

Results. Significantly increased blood plasma levels of HC, MMWP and CG were found in patients with lichen planus as compared to the control group. The patients with severe and prolonged course of dermatosis had more evident disturbances in the content of endogenous intoxication markers than those with short and mild course of the disease.

Conclusions. A significant increase in the levels of homocysteine, MMWP and carbonyl groups of oxidative modified proteins was found in the patients with LP, being indicative of an essential role of endogenous intoxication processes in the pathogenesis of lichen planus.

Keywords: lichen planus, endogenous intoxication, homocysteine.

List of abbreviations:

HC homocysteine

CG-OMP – carbonyl groups of oxidative modified proteins

MMWP – medium molecular weight peptides

Full text sources How to Cite Email to Author Format XML

Correspondence address:
Tetiana V. MELNYK
Department of Skin and Venereal Diseases, National Pirogov Memorial Medical University, Vinnytsia, Ukraine
Address: Pirogova str. no 56, Vinnytsia, 21018, Ukraine
E-mail:; Phone: +380977044804


Comments are closed.

Diaconu C. Oxidative stress and heart failure. Arch Balk Med Union 2019;54(2):219-221.