In patients with myeloproliferative neoplasms (MPNs), including essential thrombocythemia, current studies have demonstrated a JAK2V617F-dependent reactive oxygen species (ROS) elevation partially mediated by a decrease in catalase expression associated with DNA damage. Oxidative stress plays a major role in carcinogenesis as well as in genomic instability, disease progression, myelofibrotic and leukemic transformation, and possibly in the development of vascular events in patients with essential thrombocythemia. Further comprehensive studies are needed to establish the role of oxidative stress in the pathogenesis of essential thrombocythemia, disease progression, vascular complications and whether targeting ROS as a therapeutic option could prevent disease progression and the development of vascular events MPNs patients.
Keywords: essential thrombocythemia, oxidative stress, ROS, disease progression, vascular events.
„Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania