ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Clinical‑anamnestic peculiarities of the course of neonatal sepsis in newborns

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Abstract

Background. Scientific and technological progress, environmental problems of society, prolonged use of broad‑spectrum antibiotics, as well as the peculiarities of the immune response of the newborn’s body, which are accumulated on the disorders of the postnatal adaptation, contribute to the selection of microorganisms, with the formation of antibiotic‑resistant strains.

Material and methods. A retrospective analysis of medical records of newborns with neonatal sepsis, born in Chernivtsi maternity hospitals, Ukraine, during 2017 has been carried out.

Results. Among infants with neonatal sepsis, premature newborns from mothers with probable risk factors for the development of generalized bacterial infection prevailed. The disease was characterized by the symptoms of multiple organ failure, with a predominant defeat of the respiratory system, hemodynamics disorders, changes in the neurological status, and a decrease in food tolerance. According to the results of bacteriological cultures of blood, the predominance of microorganisms association was established, the leading place among them belonged to Klebsiella pneumoniae.

Conclusions. Prematurely born infants (84% in our study) prevailed among newborns with neonatal sepsis, from mothers with potential risk factors for systemic bacterial infection development. Fatal cases were observed among premature infants, especially with an extremely low body weight, which accounted for 60% of deaths, and with antibiotic resistant strains of Klebsiella pneumoniae cultures.

Keywords: early and late neonatal sepsis, newborns, epidemiological study, antibiotic resistance.

Full text sources https://doi.org/10.31688/ABMU.2018.53.3.15 How to Cite Email to Author

Address for correspondence:

Olena V. VLASOVA
Department of Pediatrics and Children’s Infectious Diseases, Higher State
Educational Institution of Ukraine “Bukovinian State Medical University“, Chernivtsi, Ukraine
Address: 58000 Chernovtsy, Fizkulturna 3\ 27 Ukraine
Email: vlasovaolena01@gmail.com; phone +380501760353

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Vlasova OV, Koliubakina LV, Krecu NM. Clinical-anamnestic peculiarities of the course of neonatal sepsis in newborns. Arch Balk Med Union 2018; 53(3):408-412. DOI 10.31688/ABMU.2018.53.3.15