Background. Autoimmune thyroiditis (AIT) is one of the unsolved problems of modern endocrinology, the etiology and pathogenesis being still insufficiently known.
Objectives. To study the effects of substitution, antioxidant and lymph-drainage therapy on the structure and function of the thyroid gland in patients with AIT and hypothyroidism.
Methods. We have identified 2 groups of patients with AIT and subclinical hypothyroidism. The first group – control group – included 20 patients who received substitution therapy with thyroxine. The second group included 33 patients who received a comprehensive treatment with thyroxine, alpha lipoic acid and Lymphomyosot.
Results. The use of substitution therapy with thyroxine and the proposed antioxidant and lymph drainage therapy in patients with AIT led to the improvement of the structure of the gland, reduced the activity of peroxide oxidation processes and the activity of pro-inflammatory cytokines, increased the level of antioxidant defense enzymes, normalized the number of aniline-positive lymphocytes, improved the lymphatic drainage function of the gland. Our results sustain the effectiveness of the proposed method of complex treatment in patients with autoimmune thyroiditis.
Keywords: autoimmune thyroiditis, antioxidant, lymph-drainage therapy.
Abbreviations: AIT – autoimmune thyroiditis; PO – peroxide oxidation; AOD – antioxidant defense; ALA – alpha lipoic acid.Full text sources https://doi.org/10.31688/ABMU.2018.53.3.10 How to Cite Email to Author
Michael I. SHEREMET
Surgery Department №1, Bukovinian State Medical University, Ukraine
Address: 58018 Chernovtsy, Holovna str., 191, Ukraine
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