ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Copper coordination compounds with thiosemicarbazones: In vitro assessment of their potential in inhibiting glioma viability and proliferation

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Introduction. Glioblastoma is the most aggressive brain tumour with very low survival rate, the development of newer therapeutic agents or strategies against it being an ongoing and intensively researched issue.
The aim of the study was to investigate in vitro the potential of 9 copper coordination compounds with benzothiazole, phenyl, and allyl thiosemicarbazones (CCT) to inhibit the viability and proliferation of rat C6 glioma cells compared to doxorubicin.
Materials and methods. We used the rat C6 glioma cell line from the American Type Culture Collection (ref CCL-107). Rat C6 glioma cells were grown in 200 mL cell culture flasks and maintained in a 3.5% CO2 incubator (ico50 Memmert GmbH Germany) at 37°C. The compounds were administered in doses of 1 μM and 10 μM. The viability was evaluated by MTT test and proliferation by resazurin one.
Results. The study results show that the compounds have selective action on in vitro viability and proliferation of C6 glioma cells that depends on the chemical structure and concentration. Conclusions. Phenyl derivatives showed a more promising action on C6 glioma cells viability and proliferation compared with benzothiazole and alyl thiosemicarbazones. Also, a lower concentration (1 μM) was more efficient than the higher one (10 μM).

Full text sources https://doi.org/10.31688/ABMU.2023.58.3.02
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Address for correspondence:
Olga TAGADIUC
Biochemistry and Clinical Biochemistry Chair, “Nicolae Testemitanu” State
University of Medicine and Pharmacy, Chisinau, Republic of Moldova
Address: 27, Nicolae Testemitanu Street, Chisinau, Republic of Moldova, MD-2025
E-mail: olga.tagadiuc@usmf.md ; Phone: +37369551321
Ecaterina PAVLOVSCHI
Biochemistry and Clinical Biochemistry Chair, “Nicolae Testemitanu” State
University of Medicine and Pharmacy, Chisinau, Republic of Moldova
Address: 27, Nicolae Testemitanu Street, Chisinau, Republic of Moldova, MD-2025
E-mail: ecaterina.pavlovschi@usmf.md ; Phone: +37379571092

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Pantea V, Andronache L, Globa P, Pavlovschi E, Gulea A, Tagadiuc O, Gudumac V. Copper coordination compounds with thiosemicarbazones: In vitro assessment of their potential
in inhibiting glioma viability and proliferation. Arch Balk Med Union. 2023;58(3):234-244. https://doi.org/10.31688/ABMU.2023.58.3.02