Introduction. Primary hepatoid carcinoma of the ovary is a very rare type of tumour that resembles hepatocellular carcinoma both histologically and immunohistochemically in its staining for alpha-fetoprotein.
Case presentation. We report the case of a 49-year-old woman who presented for abdominal pain and vaginal bleeding. Computed tomography revealed a large tumour mass of the right ovary, a micro lesion in the liver of about 0.5 cm, and many nodules on the omentum. The patient underwent total hysterectomy and bilateral salpingo-oophorectomy with tumourectomy. A right ovarian tumour mass measuring 9/8/6 cm was found. The histological diagnosis was hepatoid carcinoma of the right ovary. The serum levels of alpha- fetoprotein were high, but the immunohistochemical examination revealed a negative immunoreactivity of tumour cells for alpha-fetoprotein.
Conclusions. This is an extremely rare case of a primary hepatoid carcinoma of the ovary. The negative values of alpha-fetoprotein at immunohistochemistry do not exclude a hepatoid carcinoma. A broad panel of immunohistochemistry, including alpha-fetoprotein, HepPar(1), Glypican(3), is presented to rule out metastatic hepatocellular carcinoma in the ovary.
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CamSpasimir T. SHOPOV
Address: Department of Pathology, MBAL “Uni Hospital” Ltd, 100 Georgi
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