ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Dynamics of aldosterone, connective tissue reorganization and glucose level as markers for tuberculosis treatment effectiveness

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ABSTRACT

The objective of the study was to evaluate the dynamics of reorganization of connective tissue, aldosterone and glucose level as markers of favorable course of multidrug-resistant pulmonary tuberculosis.

Materials and methods. The study was performed on 84 patients with firstly diagnosed multidrug-resistant pulmonary tuberculosis. Aldosterone, free and protein-bound hydroxyproline and glucose levels were measured in all patients.

Results. It was found that in group I patients, free hydroxyproline levels are lower than in group II during the first two months of treatment for 60% at treatment onset and for 29.4% after 2 months of treatment. There was an increase in this index during the first 2 months of treatment in both groups. Protein-bound hydroxyproline level was higher in group I by 21.7%. The level of aldosterone at the treatment onset was almost identical in both groups. After 2 months of treatment, its level decreased in both groups. However, after 2 months of treatment in group I, its index was lower than in group II by 12.7%.

Conclusions. Our results suggest that patients with a favorable course of multidrug-resistant tuberculosis have more pronounced decrease in aldosterone level, which may act as a pro-inflammatory agent and free hydroxyproline, which is a marker for the destruction of connective tissue. Inverse correlation between protein-bound hydroxyproline and glucose levels confirm the importance of normal glucose concentration for repair process.

Keywords: multidrug-resistant tuberculosis, glucose level, aldosterone, protein-bound hydroxyproline, free hydroxyproline.

Abbreviations list

FHP – free hydroxyproline

HIV – Human Immunodeficiency Virus

HP – hydroxyproline

IP – intensive phase

MTB – Mycobacterium tuberculosis

MDR TB – Multidrug-resistant tuberculosis

PBHP – protein-bound hydroxyproline

TB – tuberculosis

THP – total hydroxyproline

Full text sources https://doi.org/10.31688/ABMU.2019.54.2.08 How to Cite Email to Author Descarca in format XML


Corresponding authors:
Lilia D. TODORIKO
Higher State Educational Establishment „Bukovinian State Medical University“, Chernivtsi, Ukraine
Address: 2, Theatralna sq., Chernivtsi – 58002, Ukraine
Email: pulmonology@bsmu.edu.ua; Phone /fax (+38 0372) 55-37-54

Iryna A. OVCHARENKO
Kharkiv National Medical University, Kharkiv, Ukraine
Address: 61022, Prosp. Nauky, 4, Kharkiv National Medical University, Department of Phthisiology and Pulmonology, Kharkiv, Ukraine
Email: arlabhf@i.ua; Phone +380673247149

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Shevchenko OS, Todoriko LD, Ovcharenko IA, et al. Dynamics of aldosterone, connective tissue reorganization and glucose level as markers for tuberculosis treatment effectiveness. Arch Balk Med Union 2019;54(2):274-280. doi.org/10.31688/ABMU.2019.54.2.08.