The objective of the study was to evaluate the dynamics of reorganization of connective tissue, aldosterone and glucose level as markers of favorable course of multidrug-resistant pulmonary tuberculosis.
Materials and methods. The study was performed on 84 patients with firstly diagnosed multidrug-resistant pulmonary tuberculosis. Aldosterone, free and protein-bound hydroxyproline and glucose levels were measured in all patients.
Results. It was found that in group I patients, free hydroxyproline levels are lower than in group II during the first two months of treatment for 60% at treatment onset and for 29.4% after 2 months of treatment. There was an increase in this index during the first 2 months of treatment in both groups. Protein-bound hydroxyproline level was higher in group I by 21.7%. The level of aldosterone at the treatment onset was almost identical in both groups. After 2 months of treatment, its level decreased in both groups. However, after 2 months of treatment in group I, its index was lower than in group II by 12.7%.
Conclusions. Our results suggest that patients with a favorable course of multidrug-resistant tuberculosis have more pronounced decrease in aldosterone level, which may act as a pro-inflammatory agent and free hydroxyproline, which is a marker for the destruction of connective tissue. Inverse correlation between protein-bound hydroxyproline and glucose levels confirm the importance of normal glucose concentration for repair process.
Keywords: multidrug-resistant tuberculosis, glucose level, aldosterone, protein-bound hydroxyproline, free hydroxyproline.
FHP – free hydroxyproline
HIV – Human Immunodeficiency Virus
HP – hydroxyproline
IP – intensive phase
MTB – Mycobacterium tuberculosis
MDR TB – Multidrug-resistant tuberculosis
PBHP – protein-bound hydroxyproline
TB – tuberculosis
THP – total hydroxyproline
Lilia D. TODORIKO
Higher State Educational Establishment „Bukovinian State Medical University“, Chernivtsi, Ukraine
Address: 2, Theatralna sq., Chernivtsi – 58002, Ukraine
Email: firstname.lastname@example.org; Phone /fax (+38 0372) 55-37-54
Iryna A. OVCHARENKO
Kharkiv National Medical University, Kharkiv, Ukraine
Address: 61022, Prosp. Nauky, 4, Kharkiv National Medical University, Department of Phthisiology and Pulmonology, Kharkiv, Ukraine
Email: email@example.com; Phone +380673247149