ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Examination of the lipid profile in pregnant obese women, considering the allele status of the genes of angiotensin-converting enzyme (ACE I/ D) and plasminogen-1 (PA-1 4G/ 5G) activator-inhibitor

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Changes in the lipid profile in pregnant women, with and without obesity, have been studied depending on the angiotensin-converting enzyme (ACE) gene I/ D polymorphism and the 4G5G polymorphism of the plasminogen activator inhibitor type I (PAI-1). The combination of the D-allele of the ACE gene and the 5G allele of the PAI-1 gene is a risk factor of increasing total cholesterol in pregnant women, regardless of the obesity class, and of increasing triglycerides in pregnant women without obesity. The presence of the D-allele of the ACE gene in the haplotype, regardless of the combinations of the genotypes of the PAI-1 gene, is a risk factor of increasing triglycerides in pregnant women with obesity.
Keywords: pregnancy, obesity, lipids, ACE gene polymorphism, PAI-1gene polymorphism

Full text sources https://doi.org/10.31688/ABMU.2018.53.2.05   How to Cite  Email to Author

Corresponding author:

BULYK Tetiana S.
Department of Obstetrics and Gynecology of the State Higher Educational Institution
of Ukraine Bukovinian State Medical University
Address: Chernivtsi, P. Orlik Str., 11/8; phone +380501080080,
e-mail: bulyk.t@bsmu.edu.ua

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Bulyk TS, Rynzhuk VY, Gresko MD, Rynzhuk LV, Sydorchuk LP, Maksimyuk VV, Malyshevskyi YO, Kryvchanska MI, Khomenko VG, Vlasova KV, Glushchenko TA, Batig VM. Examination of the lipid profile in pregnant obese women, considering the allele status of the genes of angiotensin-converting enzyme (ACE I/ D) and plasminogen-1 (PA-1 4G/ 5G) activator-inhibitor. Arch Balk Med Union, 2018, 53(2):205-209. DOI 10.31688/ABMU.2018.53.2.05