ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

The study of association between beta-3 defensins and bacteria species in peri-implantitis



 Introduction. Peri-implantitis is defined as an inflammatory process initiated by Gram-negative anaerobic bacterial species that colonize the dental implant. Human beta-3 defensin is a small cationic peptide with important antibacterial effects.

The aim of the study was to analyze the possible relationship between beta-3 defensin and Gram-negative anaerobic bacilli present in peri-implant liquid in patients with favorable evo- lution of the dental implant and in patients who have developed peri-implantitis.

Methods. The study group consisted of 36 patients, divided into three study groups after the clinical and radiological exam, as follows: 9 patients with favorable evolution of the implant; 12 patients with stage 0I and 15 patients with stage II peri-implantitis. We harvest- ed peri-implant crevicular fluid from which we quanti- fied beta-3 defensin and we performed microbiological tests.

Results. We obtained highly significant statistically differences regarding the hBD-3 values between mucositis and peri-implantitis patients (p<0.0001) and also between healthy and peri-implantitis patients (p=0.0001). The combination of bacterial species with the highest percentage representation was made up of Porphyromonas spp., Fusobacterium spp. and Tanerella  forsythia. Our study shows that there is correlation between the presence of these bacterial species and the peri-implant pocket depth (p=0.010).

Conclusion. Our study demonstrates the role of bacteria in achieving the inflammatory process within mucositis and peri-implantitis. Beta-3 defensin can be used as biomarker in monitoring the patients with peri-implantitis.

Key words: peri-implantitis, beta-3 defensin, bacteria.

Corresponding author:

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