Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease, with uveitis affecting 10–20% of patients. This systematic review evaluates biomarkers linked to JIA-associated uveitis (JIA-U) for their diagnostic, prognostic, and therapeutic potential. A literature review (2018–2024) identified 32 studies examining biomarkers in serum, aqueous humor, and tears. Key cytokines, including interleukin-6, TNF-α, and interleukin-8, were consistently associated with systemic inflammation and disease activity. S100 proteins (S100A8/A9, S100A12) emerged as specific markers for uveitis, with tear-based S100A12 and transthyretin highlighted as non-invasive biomarkers for ocular inflammation. Optical coherence tomography angiography and microRNAs also showed promise for tracking uveitis progression. Integrating these biomarkers into clinical practice could enhance early diagnosis, facilitate disease monitoring, and support personalized treatment strategies. Further research is needed to validate these biomarkers in larger cohorts and develop multi-biomarker panels for comprehensive disease management.
Keywords: biomarkers, uveitis, juvenile idiopathic arthritis, S100, cytokines, transthyretin.
Full text sources https://doi.org/10.31688/ABMU.2024.59.4.12
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Address for correspondence:
Elena GOLUBENCO
Public Healthcare Institution – Mother and Child Institute, Department of Rheumatology, Chisinau, Republic of Moldova
Address: 93, Burebista Street, Chisinau, MD-2062, Republic of Moldova
Email: enedealcova1994@gmail.com , imcopil@ms.md; Phone: +37368047239, (22) 78 12 96
