ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Neuropsychological effects of comorbidity in multiple sclerosis patients


Introduction: Multiple sclerosis (MS) is a progressive demyelinating and degenerative neurological disease. The degree of disability increases along with pathological damage, especially in cases with comorbidity.
Methodology: The objective of this study was to analyze the influence of MS alone and with comorbidity on some neuropsychological patterns. Individual quality of life of 80 MS patients at a mean age of 49 years, 56 females and 24 males, was examined by means of Multiple Sclerosis Quality of Life-54 Questionnaire (MSQOL-54) in 2002-2015. Forty patients presented with MS alone and 40 with MS and comorbidity. The frequency of troubles of mental concentration/thinking, fixation of attention, and memory as well as of difficulty at work and other activities were examined.
Results: Statistically significant differences were observed between patients with MS alone and those with MS and comorbidity concerning troubles of mental concentration/thinking (t=4.822; p<0.0001), and of memory (t=4.020; p<0.0001). Gender correlated negatively with troubles of memory (R=-0.343; r<0.05), while EDSS scores did with troubles of memory (R=-0.346; p<0.05) and with troubles of attention (R=-0.330; p<0.05). The accompanying diseases additionally worsened the components of health-related quality of life.
Conclusions: Common comorbidity in MS patients requires careful clinical examinations and proper management in order to reduce the neuropsychological burden and assure a better individual quality of life for the patient.
Key words: multiple sclerosis, quality of life, comorbidity, neuropsychological impairment

Corresponding author:

First Multiprofile Clinic of Neurology, Department of Neurology and Neurosciences
St. Marina University Hospital of Varna, Medical University of Varna
1 Hristo Smirnenski Street, Varna 9010, Bulgaria
Mobile phone: 0888306776; e-mail:

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