Schistosomiasis, a parasitic disease caused by Schistosoma trematode worms, poses a substantial global health threat, affecting over 800 million individuals across 76 endemic countries. Predominantly caused by Schistosoma haematobium, Schistosoma japonicum, and Schistosoma mansoni, the disease thrives in regions with inadequate sanitation and hygiene practices. Despite its significant impact, current diagnostic methods lack affordability, precision, and straightforwardness, hindering effective disease control.
This manuscript extensively reviews various diagnostic approaches, encompassing parasitological, immunological, and molecular techniques. The need for novel, cost-effective, and highly sensitive diagnostic tools, especially in low-transmission regions, is emphasized. The manuscript also delves into the complexities of managing schistosomiasis, primarily reliant on the administration of praziquantel. While effective, challenges such as side effects and potential resistance necessitate ongoing research. The combination of artemisin derivatives with praziquantel presents a promising avenue for enhanced treatment outcomes. In conclusion, the manuscript underscores the urgency of advancing diagnostics and therapeutics, alongside strategic interventions for interrupting disease transmission, to comprehensively address the global impact of schistosomiasis.
Keywords: Schistosomiasis, praziquantel, parasitic disease, trematode worms, schistosomes.
Full text sources https://doi.org/10.31688/ABMU.2024.59.1.14
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Address for correspondence:
Yusuf Haz CONDENG
Department of Internal Medicine, Hasanuddin University, Makassar, Indonesia
Email: yusufhazcondeng@gmail.com
