The objective of the study was to determine the characteristics of bone mineral density in patients with osteoarthritis (OA), non-alcoholic steatohepatitis (NASH) and obesity.
Material and methods. 90 patients were examined and distributed into three groups: group 1 (n = 30) consisted of patients suffering from OA of knee joints, grade 2-3 according to Kellgren and Lawrense classification,with normal body weight (mean BMI 22.88±0.39 Kg/m2); group 2 (n = 30) – patients with OA with NASH and obesity (mean BMI 34.38±0.69 Kg/m2). The control group consisted of 30 healthy subjects of the corresponding age. The average age of patients was 62.3±5.7 years.The bone mineral density (BMD) at the level of the proximal femoral bone was evaluated on a dual-energy X-ray densitometer using the STRATOS apparatus DMS-APELEM (France) under a densitometry cabinet based on the Swedish-Ukrainian Medical Center “Angelholm”, Chernivtsi, Ukraine. The diagnosis of osteoporosis and low BMD was done according to the criteria of the ISCD Official Positions, 2007 (revised in 2015). Statistical analysis was performed using SPSS Statistics 20 Multilingual.
Results. Osteoporosis and low BMD were found to be significantly higher in patients with osteoarthritis compared with those from the group withosteoarthritis, NASH and obesity.
Conclusions. In patients with isolated osteoarthritis, a significant decrease of bone mineral density was found, especially in the intertrochanteric region of the femur. In individuals suffering from OA, the risk of fractures was higher than in those with concomitant NASH and obesity. The difference was significant only in the case of osteoporotic and femur fracture, without considering BMD.
Keywords: non-alcoholic steatohepatitis, osteoporosis, mineral density of bone tissue, obesity.
List of abbreviations:
NAFLD = non-alcoholic fatty liver disease
NASH = non-alcoholic steatohepatitis
OA = osteoarthritis
OB = obesity
BMI = body mass index
PHP = practically healthy persons
BMD= bone mineral density
SD= standard deviation
DXA= dual-energy X-ray absorptiometry
Department of Internal Medicine, Clinical Pharmacology and Occupational Diseases, Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine
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