ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Characteristics of bone mineral density and densitometry data in patients with osteoarthritis, non-alcoholic steatohepatitis and obesity

46 views

ABSTRACT

The objective of the study was to determine the characteristics of bone mineral density in patients with osteoarthritis (OA), non-alcoholic steatohepatitis (NASH) and obesity.

Material and methods. 90 patients were examined and distributed into three groups: group 1 (n = 30) consisted of patients suffering from OA of knee joints, grade 2-3 according to Kellgren and Lawrense classification,with normal body weight (mean BMI 22.88±0.39 Kg/m2); group 2 (n = 30) – patients with OA with NASH and obesity (mean BMI 34.38±0.69 Kg/m2). The control group consisted of 30 healthy subjects of the corresponding age. The average age of patients was 62.3±5.7 years.The bone mineral density (BMD) at the level of the proximal femoral bone was evaluated on a dual-energy X-ray densitometer using the STRATOS apparatus DMS-APELEM (France) under a densitometry cabinet based on the Swedish-Ukrainian Medical Center “Angelholm”, Chernivtsi, Ukraine. The diagnosis of osteoporosis and low BMD was done according to the criteria of the ISCD Official Positions, 2007 (revised in 2015). Statistical analysis was performed using SPSS Statistics 20 Multilingual.

Results. Osteoporosis and low BMD were found to be significantly higher in patients with osteoarthritis compared with those from the group withosteoarthritis, NASH and obesity.

Conclusions. In patients with isolated osteoarthritis, a significant decrease of bone mineral density was found, especially in the intertrochanteric region of the femur. In individuals suffering from OA, the risk of fractures was higher than in those with concomitant NASH and obesity. The difference was significant only in the case of osteoporotic and femur fracture, without considering BMD.

Keywords: non-alcoholic steatohepatitis, osteoporosis, mineral density of bone tissue, obesity.

List of abbreviations:

NAFLD = non-alcoholic fatty liver disease

NASH = non-alcoholic steatohepatitis

OA = osteoarthritis

OB = obesity

BMI = body mass index

PHP = practically healthy persons

OP= osteoporosis
BMD= bone mineral density

SD= standard deviation

DXA= dual-energy X-ray absorptiometry

Full text sources https://doi.org/10.31688/ABMU.2019.54.3.10 How to Cite Email to Author Format XML


Correspondence address:
OksanaD. LIAKHOVYCH
Department of Internal Medicine, Clinical Pharmacology and Occupational Diseases, Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine
Email: ksiusuk@gmail.com;Phone +380506222407

Share.

Comments are closed.

Diaconu C. Oxidative stress and heart failure. Arch Balk Med Union 2019;54(2):219-221. doi.org/10.31688/ABMU.2019.54.2.219