ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Endometriosis and impaired placentation: A prospective cohort study comparing PLGF in pregnancies of patients with and without endometriosis


Introduction. Endometriosis is a chronic condition that affects 10% of women of childbearing age. Pregnancies associated with endometriosis have additional risks, such as preeclampsia, preterm birth, and foetal growth restriction.
The objective of the study was to investigate if endometriosis affects placental function during pregnancy, measured by placental growth factor (PLGF) when compared to unaffected patients.
Material and methods. In this prospective cohort study, we enrolled pregnant women with endometriosis according to laparoscopic findings, who were matched for body mass index and parity in a 1:1 ratio with healthy patients. Pregnant women with endometriosis were compared to non-endometriosis patients and assessed for PLGF and pregnancy-associated plasma protein A (PAPP-A) at 11-14 weeks of gestation. Preeclampsia was noted in the third trimester.
Results. The study found that patients with endometriosis had significantly lower PLGF levels compared to control (p = 0.003). In our study, endometriosis was associated with decreased PLGF levels and preeclampsia (p = 0.026).
Conclusions. According to these results, endometriosis is associated with a clinically measurable impaired late placental perfusion. It is recommended that patients with endometriosis must have a closer follow up for better prediction and prevention of perinatal and pregnancy outcomes due to impaired perfusion of the placenta.
Keywords: endometriosis, placenta, uterine arteries, PLGF.

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Address for correspondence:
Bulevardul Ion C. Bratianu 1, Bucuresti 030167, Integrated Ambulatory

Draga M. MANDI
Bulevardul Ion C. Bratianu 1, Bucuresti 030167, General Surgery Departament
Email:, Phone +40724636055


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Costache CR, Mandi DM, Costache Outas MC, Burcos T. Endometriosis and impaired placentation: a prospective cohort study comparing PLGF in pregnancies of patients with and without endometriosis. Arch Balk Med Union. 2024;59(2):167-173.