ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Gout and renal dysfunction


Introduction. The frequency of nephrolithiasis positively correlates with the degree of hyperuricemia.
The objective of the study was the analysis of renal dysfunction in patients with gout from different age groups.
Material and methods. 237 patients with gout (mean age for males 60 ± 8.0 years and females 63 ± 9.0 years) were examined and analyzed retrospectively. The diagnosis of gout was carried out according to the classification criteria for gout of the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) 2015. The patients were separated into two groups, depending on the age at gout onset: the age at onset up to and including 59 years (group I, 91 people) and the age at onset after 60 years, inclusive (gro¬up II, 146 people). The raw data was processed in SPSS version 26.0.
Results. The renal function was mostly preserved in patients from group I: 51% had a level of glomerular filtration rate (GFR) corresponding to stage 2 chronic kidney disease (CKD) (in the presence of kidney damage), stage 4 CKD was determined in only 2 patients from group I. A pronounced decrease in kidney function was determined in group II, significantly more often there was stage 3 CKD (16 (22%) in group I and 59 (46%) in group II, p = 0.001). In 12 participants in group II, GFR was below 29 ml/min/1.73 m2. Only in 6% of cases, a slight decrease in GFR was determined, which was 4 times lower than in group I.
Conclusions. With increasing age, the frequency of risk factors for gout increases, especially for people with kidney damage: taking small doses of acetylsalicylic acid increases the risk from 6 to 40%, diuretics from 18 to 44%, alcohol consumption from 14 to 28%, hypertension from 44 to 78%, consumption of foods saturated with purine from 51 to 68%, overweightness and obesity from 58 to 76%.
Keywords: gout, renal dysfunction, risk factors, uric acid, diuretics.

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Address for correspondence:
Department of Internal Medicine, Rheumatology and Nephrology Discipline, “Nicolae Testemitanu” State University of Medicine and Pharmacy, Chisinau, Republic of Moldova
Address: Nicolae Testemitanu Street, no. 29, Chisinau MD 2024, Republic of Moldova


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Rotaru L, Groppa L, Ceban E, Russu E, Pascal R, Sasu D, Cornea C. Gout and renal dysfunction. Arch Balk Med Union. 2023;58(4):382-387.