ISSN ONLINE: 2558-815X
ISSN PRINT: 1584-9244
ISSN-L: 1584-9244

Organometric changes of rats thymus after xenobiotics exposure



Background. Pollution of the environment poses major risks for human health. Chronic exposure to some well-absorbed but slowly eliminated xenobiotics can lead to their bioaccumulation in living organisms.

The objective of the study was to describe the organometric changes occurring in thymus of male rats under tryglycidyl ether of polyoxypropylenetriol exposure.

Material and methods. 40 WAG matured male rats were divided randomly into two groups. The first group served as a control included 8 animals. The second group of 32 rats, 8 rodents in each, were treated via gavage by aqueous solutions of tryglycidyl ether of polyoxypropylenetriol (TEPPT) in  a dose of 1/10 LD50 in conversion to 5.75 g/kg during 7, 15, 30, 45 days. All animals were sacrificed on the term defined by experimental design. Thymus specimens were dissected out and measurements of the linear dimensions (length, width, height) using digital caliper were taken. The mass and volume of the thymus were counted. Limits of the thymus morphometric indices’ variability in intact and experimental groups were calculated.

Results. The research indicates that tryglycidyl ether of polyoxypropylenetriol exposure caused marked organometric changes in rats’ thymus. 100% effect on all morphometric indices of the thymus under impact of TEEPT in a dose of 1/10 LD50 on the 7th, 15th, 30th and 45th day was noted. However, more pronounced changes were observed on 7th and 30th days. The study revealed that IndT of the control group, which is related to the length and width of the thymus, has the greatest limits of the parameters’ fluctuations and their significant variability. IndHL of the control group, which is associated with the height and length of the thymus, has the lowest fluctuation limits of the parameters. In our opinion, this is connected, first of all, with the peculiarities of the structure and form of the rats’ thymus.

Conclusions. Thymus shows active response on the induced xenobiotic and these data can be successfully extrapolated from experimental animals to humans.

Keywords: thymus, rats, xenobiotics, organometry, polyethers.

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Shyian D, Avilova O, Ladnaya I. Organometric changes of rats thymus after xenobiotics exposure. Arch Balk Med Union. 2019;54(3):422-430