Introduction. One of medical-social chronic consequences of diabetes mellitus is encephalopathy, with an advancing course and development of neurodegenerative disorders in the central nervous system.
Objective: to examine carbacetam effect as a new modulator of gamma-aminobutyric acid activity on protein peroxide oxidation and morphological condition of the cerebral cortex and hippocampus in rats under conditions of experimental neurodegeneration in case of type 2 diabetes mellitus.
Materials and methods. Changes in the content of protein peroxide oxidation in the cerebral cortex and hippocampus under effect of carbacetam (5 mg/kg) are examined in nonlinear laboratory albino male rats with neurodegeneration under conditions of type 2 diabetes mellitus simulated by streptozotocin and high-fat diet.
Results. In rats with type 2 diabetes mellitus, the degree of protein peroxide oxidation in the cerebral cortex and hippocampus increases, which is associated with increased amount of cells with karyopyknosis, decreased relative density of staining of the neuron tigroid substance and partial denudation of vessels. After carbacetam administration during 14 days in rats with type 2 diabetes mellitus in the cerebral cortex and hippocampus the level of protein peroxide oxidation decreases, the amount of cells with karyopyknosis reduces, a relative density of staining of the neuron tigroid substance increases, and denudation of vessels is lacking.
Conclusions. Decreased intensity of the protein peroxide oxidation processes, histological destruction of the cerebral cortex and hippocampus are indicative of a neuroprotective potential of carbacetam under conditions of neurodegeneration caused by type 2 diabetes mellitus.
Keywords: type 2 diabetes mellitus, neurodegeneration, carbacetam, protein oxidation modification.
Abbreviations: CNS – central nervous system, DM – diabetes mellitus, GABA – gamma-aminobutyric acid, PPO – protein peroxide oxidation, POM – protein oxidation modification.
Olga G. KMET
Department of Pharmacology of the Higher State Educational Establishment of Ukraine
„Bukovinian State Medical University”, Ukraine
Address: Teatralna Sq. 2, Chernivtsi, 58002, Ukraine
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