Introduction. Oxidative stress (OS) plays an important role in the development of community-acquired pneumonia (CAP) and is involved in many cardiovascular diseases, including heart failure (HF).
The objective of the study was to analyse OS markers in patients with CAP and pre-existing HF.
Material and methods. This was a prospective study, conducted in the Department of Internal Medicine, “Nicolae Testemitanu” State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, between October 2019 – October 2023. The study included 210 patients with CAP. The patients were divided into two groups: group 1 – 105 patients with CAP and pre-existing HF, group 2 – 105 patients with CAP without chronic HF. The values of prooxidant and antioxidant markers were determined in all patients.
Results. The age of the patients in the study group varied between 50 and 92 years, with a mean age of 70.6±8.89 years. Ischemic modified albumin had lower values in group 1 compared to group 2 (229.77±57.23 µM/L and 236.60±64.35 µM/L, respectively, p>0.05). Advanced glycation end products (AGE)-pentosidin-like values were higher in patients from group 1 (598.79±251.68 µM/L) versus group 2 (544.55±197.20 µM/L), p>0.05. Total cupric antioxidant activity had higher values in patients from group 1 (6.70±4.62 mM/L) versus group 2 (4.99±4.29 mM/L), p<0.05.
Conclusions. CAP in patients with pre-existing HF involves not only the respiratory system, but is characterized by systemic inflammation, imbalance between oxidant and antioxidant system.
Keywords: community-acquired pneumonia, heart failure, oxidative-stress markers.
Full text sources https://doi.org/10.31688/ABMU.2024.59.4.02
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Virginia CASCAVAL
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