Introduction: Urinary tract infections in pregnant women complicate the course of pregnancy. It is necessary to know not only the pathogen type but also to prescribe the safest antibiotics for adequate treatment of urinary tract infections. Materials and methods: The material for the study was urine. The study was conducted by a quantitative method. The identification of microorganisms was realized by MALDI-TOF, using mass-spectrometer Microflex (Bruker). Determination of the sensitivity of the isolated strains to antimicrobial agents was performed by disk methods in accordance with the recommendations of CLSI (2012). Statistical processing was performed using WhoNet 6.3 program.
Results: The results of the research showed that the positive samples with a titer 10^6-10^8 CFU ml were obtained in 87 pregnant women. E. coli were isolated in 55.17% cases. The most active antibacterial agents against E.coli were the drugs of fluoroquinolones group. All E. coli strains were susceptible to fosfomycin, trimethoprim, amikacin, isepamicin, netilmicin. High activity had nitrofurantoin (93.8%), ampicillin-sulbactam (97.3%), gentamicin and sisomicin (95.2%). 53.3% isolated E. coli strains were sensitive to ampicillin.
Conclusion: The prevalence of urinary tract infections in pregnant women was 22.5%. E. coli was the most common causative agent of urinary tract infections in pregnant women. High antibacterial activity was registered in cephalosporins, fosfomycin, and nitrafurantoin.Full text sources